期刊
CLINICAL IMMUNOLOGY
卷 206, 期 -, 页码 15-22出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2018.09.002
关键词
Psoriatic arthritis; Skin and joint inflammation; Cytokines; IL-23/IL-23R pathways; Human monoclonal IL-23 antibodies; Therapeutics
类别
资金
- National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases [R01AR062173]
- National Psoriasis Foundation Translational Research grant
Psoriatic arthritis (PsA) is a chronic inflammatory arthritis of unknown etiology, and currently the cellular and molecular interactions that dictate its pathogenesis remain elusive. A role of the interleukin-23 (IL-23)/IL-23R (IL-23 receptor) interaction in the development of psoriasis and PsA is well established. As IL-23 regulates the differentiation and activation of innate and adaptive immunity, it pertains to a very complex pathophysiology involving a plethora of effectors and transducers. In this review, we will discuss recent advances on the cellular and molecular pathophysiological mechanisms that regulate the initiation and progression of PsA as well as new therapeutic approaches for IL-23/IL-23R targeted therapeutics.
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