期刊
CLINICAL IMMUNOLOGY
卷 155, 期 2, 页码 213-219出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2014.10.005
关键词
Trained immunity; BCG; Innate immunity; Vaccination
类别
资金
- Vici Grant of the Netherlands Organization for Scientific Research
- Vidi Grant of the Netherlands Organization for Scientific Research
- US National Institutes of Health
- Helmsley Trust [AI 062773, DK 043351, DK 83756]
Adaptive features of innate immunity, also termed 'trained immunity', have recently been shown to characterize monocytes of BCG vaccinated healthy volunteers. Trained immunity leads to increased cytokine production in response to non-related pathogens via epigenetic reprogramming of monocytes. Recently, memory-like properties were also observed in NK cells during viral infections, but it is unknown if memory properties of NK cells contribute to trained immunity due to BCG vaccination. BCG vaccination of healthy volunteers increased proinflammatory cytokine production following ex vivo stimulation of NK cells with mycobacteria and other unrelated pathogens up until at least three months after vaccination. In addition, in a murine model of disseminated candidiasis, BCG vaccination led to an increased survival in SOD mice, which was partially dependent on NK cells. These findings suggest that NK cells may contribute to the non-specific (heterologous) beneficial effects of BCG vaccination. (C) 2014 Elsevier Inc. All rights reserved.
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