期刊
CLINICAL IMMUNOLOGY
卷 149, 期 3, 页码 475-486出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2013.10.003
关键词
IGHG (Fc gamma) (GM) genes; Innate IgG molecules and B cells; IgG related diseases; Active and passive immunotherapies
类别
The distinguished alternative GM allotypes localized in immunoglobulin constant heavy G chain IGHG (Fc gamma) (GM) genes on chromosome 14q32.3 define two unique variants of respectively IgG3, IgG1 and IgG2 subclasses, with different structures and functions. The IGHG allele (allotypes), expressed in homozygous or heterozygous forms, are assessed by new serological methods. Fixed combinations of gamma 3, gamma 1 and gamma 2 allotypes constitute the haplotypes, which are indirect markers of B cells. We highlight the role of homozygous IGHG genes with restricted qualities of IgG subclass molecules and B cells. These common Mendelian IGHG genes respond differently to allergens and infections, both bacterial and viral, and to active and passive immunotherapies. IGHG genes have an impact on diseases such as allergy, immunodeficiency, autoimmunity and malignancy. Association/linkage of different IGHG genes gives information about risk/protection, good or bad prognosis, for improvement of clinical care. The IGHG gene map of healthy Caucasians is registered. (C) 2013 Elsevier Inc. All rights reserved.
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