期刊
CLINICAL IMMUNOLOGY
卷 139, 期 3, 页码 267-276出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2011.02.009
关键词
Contact hypersensitivity; Repressor of GATA (ROG); Th2 responses; Mast cell degranulation
类别
资金
- Global Center for Education and Research in Immune System Regulation and Treatment
- MEXT (Japan)
- Ministry of Education, Culture, Sports, Science and Technology (Japan) [17016010, 20060003, 21390147, 22790452]
- Ministry of Health, Labor and Welfare (Japan)
- Grants-in-Aid for Scientific Research [21390147, 22790452, 20060003, 23659240, 22021008] Funding Source: KAKEN
Repressor of GATA (ROG) inhibits Th2 cell differentiation and allergic airway inflammation in the lung. To determine the role of ROG in the pathogenesis of contact hypersensitivity (CHS), a hapten-induced mouse model of CHS using ROG Tg and ROG-deficient (ROG(-/-)) was used. ROG Tg mice showed little ear swelling, while ROG(-/-) mice showed enhanced ear swelling in comparison to wild type mice. Interstitial edema and mast cell degranulation at the local inflammation sites were mild in ROG Tg mice and exacerbated in ROG(-/-) mice. In addition, the serum total IgE and hapten-specific IgG1 levels were increased in ROG(-/-) mice. Adoptive transfer of ROG(-/-) CD4(+) T cells exacerbated CHS in wild type mice, while transfer of ROG Tg CD4(+) T cells resulted in the attenuation of CHS. These results indicate ROG negatively regulates the induction of CHS by controlling the CD4(+) T cell-mediated allergic responses, including IgE generation and mast cell degranulation. (C) 2011 Elsevier Inc. All rights reserved.
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