期刊
CLINICAL IMMUNOLOGY
卷 135, 期 3, 页码 422-429出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2010.01.001
关键词
Intravenous immunoglobulins; Antigen presentation; B cells
类别
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Fonds quebecois de la recherche sur La nature et les technologies (FQRNT)
- Bayer/Talecris/CBS/HQ Partnership Fund
Previous work from our laboratory revealed that IVIg interacted with intracellular proteins involved in antigen presentation in B cells, suggesting that IVIg might interfere with the process of antigen presentation in these cells. In the present work, we used an in vitro assay with ovalbumin as model antigen and showed that IVIg inhibited both BCR-dependent and BCR-independent antigen presentation. The inhibition could not be explained by a modulation of expression of MHC II molecules expressed on B cells and was shown to occur in an Fc gamma RIIb-independent manner, suggesting that the events responsible for the inhibitory effect occur at the intracellular level. This was supported by the observation of a direct correlation between the level of spontaneous internalization of two different proteins (IVIg and HSA) and their inhibitory potential. The inhibition of B cell-mediated antigen presentation reported here may help explain some of the anti-inflammatory effects of IVIg observed in treated patients, such as a decrease in autoantibody production. (C) 2010 Elsevier Inc. All rights reserved.
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