期刊
CLINICAL IMMUNOLOGY
卷 130, 期 3, 页码 280-289出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2008.09.006
关键词
CD4; CD8; Memory; HIV-1; Infants
类别
资金
- NIAID NIH HHS [R01 AI065653-04, R01 AI065653-03, R01 AI065653-01, R01 AI065653-02, N01AI70022, N01-AI7002] Funding Source: Medline
HIV-1 infection causes a severe T cell compromise; however, littte is known about changes in naive, memory, effector and senescent T cell subsets during the first year of life. T cell subsets were studied over the first year of life in blood from 3 infant cohorts: untreated HIV-infected, HIV-exposed but uninfected, and HIV-unexposed. In HIV-infected infants, the frequency of CCR7(+)CD45RA(+) naive CD8(+) T cells was significantly decreased, while the frequency of CCR7(-)CD45RA(-) effector memory CD8(+) T cells was increased, compared with the control cohorts. A larger population of CD8(+) T cells in HIV-infected infants displayed a phenotype consistent with senescence. Differences in CD4(+) T cell subset frequencies were less pronounced, and no significant differences were observed between exposed and unexposed HIV-uninfected infants. We concluded that the proportion of naive, memory, effector and senescent CD8(+) T cells during the first year of life is significantly altered by HIV-1 infection. (C) 2008 Elsevier Inc. All rights reserved.
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