期刊
CLINICAL IMMUNOLOGY
卷 127, 期 1, 页码 107-118出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2007.12.002
关键词
immunosenescence; aging; T-cell subset; T-cell homeostasis; CD4; CD8; killer; immunoglobulin-like receptors; CD85
类别
资金
- NCATS NIH HHS [UL1 TR000454] Funding Source: Medline
- NCRR NIH HHS [M01 RR00039, M01 RR000039] Funding Source: Medline
- NIAID NIH HHS [R01 AI 57266, U19 AI057266, U19 AI057266-05S10003] Funding Source: Medline
- NIAMS NIH HHS [R01 AR042527] Funding Source: Medline
- NIA NIH HHS [R01 AG015043, R01 AG 15043, R01 AG015043-10] Funding Source: Medline
- NIGMS NIH HHS [T32 GM008169] Funding Source: Medline
With increasing age, the competence of the immune system to fight infections and tumors declines. Age-dependent changes have been mostly described for human CD8 T cells, raising the question of whether the response patterns for CD4 T cells are different. Gene expression arrays of memory CD4 T cells yielded a similar age-induced fingerprint as has been described for CD8 T cells. In cross-sectional studies, the phenotypic changes were not qualitatively different for CD4 and CD8 T cells, but occurred much more frequently in CD8T cells. Homeostatic stability partially explained this lesser age sensitivity of CD4 T cells. With aging, naive and central memory CD8 T cells were lost at the expense of phenotypically distinct CD8 effector T cells, white effector CD4 T cells did not accumulate. However, phenotypic shifts on central memory Tcells were also more pronounced in CD8 T cells. This distinct stability in cell surface marker expression can be reproduced in vitro. The data show that CD8 T cells are age sensitive by at least two partially independent mechanisms: fragile homeostatic control and gene expression instability in a large set of regulatory cell surface molecules. (C) 2007 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据