期刊
CLINICAL IMMUNOLOGY
卷 127, 期 2, 页码 138-143出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2007.12.003
关键词
type 1 diabetes; partial remission; honeymoon; ELISPOT; IL-10; FoxP3
类别
The immune phenotype of the partial remission phase or honeymoon phase of type 1 diabetes is not welt defined. We compared flow cytometry and cytokine production by ELISPOT assays in children with newly diagnosed type 1 diabetes and children in the partial remission phase of type 1 diabetes. Newly diagnosed children had higher levels of FoxP3 expression in CD4 CD25 double positive cells (56.1%+/-24.9 vs. 24.9%+/-24.6 p=0.03) and higher mean numbers of IL-10 producing cells (7.3 cells/2 x 10(5) cells+/-6.6 vs. 0.86 cells/2 x 10(5) +/-0.36 p=0.0043) compared to partial remission patients. Higher FoxP3 expression at diagnosis predicted worse future glycemic control white higher mean numbers of IL-10 cells were associated with better future glucose control. These data provide an immune phenotype of the honeymoon phase and suggest that analyzing IL-10 and FoxP3 at diagnosis may identify patients that will experience better glucose control. (C) 2007 Elsevier Inc. All rights reserved.
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