期刊
CLINICAL IMMUNOLOGY
卷 126, 期 3, 页码 332-337出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2007.11.006
关键词
atopic dermatitis; loricrin; involucrin; Th2 cytokines; STAT-6
类别
资金
- NCRR NIH HHS [M01 RR 00051, M01 RR000051-457759, M01 RR000051] Funding Source: Medline
- NIAID NIH HHS [N01 AI 40029, N01 AI040029, U01 AI147462, N01 AI 40030, N01AI40030] Funding Source: Medline
- NIAMS NIH HHS [R01 AR041256, R21 AR051634, R01 AR041256-16, AR 41256, R21 AR 051634-01] Funding Source: Medline
Atopic dermatitis (AD) is characterized by a defective skin barrier which allows increased allergen and pathogen penetration. Loricrin (LOR) and involucrin (IVL) are proteins important for skin barrier formation and integrity. In this study, we demonstrate that the gene and protein expression of LOR and IVL is significantly decreased in involved (LOR: p < 0.001; IVL: p < 0.001) and uninvolved (LOR: p < 0.001; IVL: p < 0.001) skin of AD subjects, as compared to skin from healthy subjects. Using primary keratinocytes, we further demonstrate the downregulatory effect of IL-4 and IL-13 - which are over-expressed in the skin of AD patients - on LOR and IVL expression in keratinocytes. Additionally, skin biopsies from signal transducer and activator of transcription (STAT)-6 transgenic mice were deficient in the expression and production of LOR and IVL. This study suggests that Th2 cytokines inhibit expression of LOR and IVL through a STAT-6 dependent mechanism. (c) 2007 Elsevier Inc. Alt rights reserved.
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