期刊
CLINICAL IMMUNOLOGY
卷 128, 期 3, 页码 415-426出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2008.04.012
关键词
autoantibodies; epitope mapping; bullous pemphigoid; BP180; BP230
类别
资金
- European Community [QLG1-CT-2001-02007]
- German Research Council (DFG) [BR1475/6-3, HE1602/8-1]
- Wilhelm Sander-Stiftung [2004.120.1]
- Swiss National Science Foundation [3100A-109811/1]
Bullous pemphigoid (BP) is an autoimmune bullous disease, associated with autoantibodies directed against the hemidesmosomal components BP180 and BP230. In this study for the first time different laboratories have analyzed the autoantibody profile in the same group of 49 prospectively recruited BP patients. The results show that: 1) disease severity and activity correlated with levels of IgG against the BP180-NC16A domain, but also against a COOH-terminal epitope of BP180, 2) distinct epitopes of the BP180 ectodomain other than BP180-NC16A were recognized by 96% of the BP sera; and 3) the combined use of BP180 and BP230 ELISA led to the detection of IgG autoantibodies in all the BP sera. These results demonstrate the usefulness of the combined ELISAs based on various BP180 and BP230 fragments in establishing the diagnosis of BP and support the concept that BP180 is the major autoantigen of BR (C) 2008 Elsevier Inc. All rights reserved.
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