期刊
CLINICAL IMMUNOLOGY
卷 128, 期 3, 页码 314-321出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2008.02.013
关键词
CVID; IgM memory B cells; switched memory B cells; pneumococcal antibody; sex differences; IgG; splenectomy
类别
资金
- National Institutes of Health [AI 101093, AI-467320, AI-48693]
- NIAID [03-22]
- Fondo de Investigacion Sanitaria [FIS, BA07/90049]
Common variable immunodeficiency (CVID) is a heterogeneous syndrome characterized by impaired antibody responses, recurrent infections, inflammatory, autoimmune and malignancy- related conditions. We evaluated the relationship between memory B cell phenotype, sex, age at diagnosis, immunologic and clinical conditions in 105 CVID subjects from one medical center. Reduced numbers of switched memory B cells (cutoff <= 0.55% of B cells) were an independent risk factor of granulomas, autoimmune diseases and splenomegaly (p<0.001). Not previously noted, CVID females had significantly more switched memory cells (p=0.007) than mates. Splenectomized subjects did not have fewer IgM memory B cells and these numbers were not related to the development of lung disease, as previously proposed. Lower baseline serum IgG was an independent predictor of pneumonia (p=0.007) and severe infections (p=0.001). We conclude that outcomes in CVID depend on an interplay of factors including sex, numbers of switched memory B cells, and baseline serum IgG and IgA levels. (C) 2008 Elsevier Inc. All rights reserved.
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