期刊
CLINICAL IMMUNOLOGY
卷 128, 期 1, 页码 1-7出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2008.04.004
关键词
lupus; T cells; cryoglobulins; complement
类别
资金
- NIAID NIH HHS [R01 AI042269, R01 AI042269-12A1] Funding Source: Medline
We discuss a 53-year-old woman with systemic Lupus erythematosus who presented with vasculitis, hypocomplementemia and nephritis. Although her serum complement 4 (C4) levels were zero, she had four copies of C4 gene. Renal biopsy revealed membranoproliferative glomerulonephritis and the presence of cryoglobulins, detected by electron microscopy, and significant numbers of T cells in the interstitium. Cryoglobulins were considered responsible for the complete consumption of C4 in the serum the levels of which improved gradually after treatment. T cells in the kidney were found to express CD44 and phosphorylated ezrin/radixin/moiesin which explain why they homed to the kidney inappropriately. The contribution of cryoglobulins and T cells in the expression of kidney pathology is discussed. (C) 2008 Elsevier Inc. All rights reserved.
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