Gallbladder complications associated with molecular targeted therapies: clinical and imaging features

Objectives: To evaluate the clinical and imaging features of molecular target therapies (MTT)-associated gallbladder complications. Methods: The clinical presentation, imaging features, management, and outcome in six consecutive patients, who developed gallbladder complications while on monotherapy with MIT, were studied. Results: Imaging features included gallbladder distension, edema, hyperemia, pericholecystic fluid, and stranding. Two of the six patients were asymptomatic and continued the drug due to good response. Four of the six patients developed acute cholecystitis and required drug discontinuation temporarily or permanently with 2/4 patients requiring surgery. Conclusion: MIT can be associated with gallbladder complications that may need temporary or permanent discontinuation of the associated drug. (C) 2014 Elsevier Inc. All rights reserved.