期刊
JOURNAL OF MAGNETIC RESONANCE IMAGING
卷 43, 期 1, 页码 75-87出版社
WILEY
DOI: 10.1002/jmri.24967
关键词
diabetes mellitus; spatial working memory; cognitive function; functional magnetic resonance imaging
资金
- National Natural Science Foundation of China [81373745, 81072905, 81370925]
- Natural Science Foundation of Guangdong Province of China [S2011010005019, 10151503102000015]
- Science and Technology Planning Project of Guangdong Province of China [2009B030801323, 2010B031600023]
- Shantou Technology Bureau Science Foundation of China
- Shantou Government Technology [[2006] 85, [2011] 46]
Purpose: To explore mild cognitive dysfunction and/or spatial working memory impairment in patients with primary onset middle-age type 2 diabetes mellitus (T2DM] using ethology (behavior tests) and blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI). Materials and Methods: Eighteen primary onset T2DM patients and 18 matched subjects with normal blood glucose levels were all tested using the Montreal cognitive assessment scale test, the Wechsler Memory Scale Chinese-revised test, and scanned using BOLD-fMRI (1.5T, EPI sequence) while performing the n-back task to find the activation intensity of some cognition-related areas. Results: The ethology results showed that T2DM patients had a mild cognitive impairment and memory dysfunction (P<0.05). The fMRI scan identified a neural network consisting of bilateral dorsolateral prefrontal cortex (DLPFC), bilateral premotor area (PreMA), bilateral parietal lobe (PA), and anterior cingulate cortex (ACC)/supplementary motor area (SMA) that was activated during the n-back task, with right hemisphere dominance. However, only the right PA and ACC/SMA showed a load effect via quantitative analysis in the T2DM group; the activation intensity of most working memory-related brain areas for the T2DM group were lower than for the control group under three memory loads. Furthermore, we found that the activation intensity of some cognition-related areas, including the right insular lobe, left caudate nucleus, and bilateral hippocampus/parahippocampal gyrus were lower than the control group under the memory loads. Conclusion: Diabetes-related brain damage of primary onset middle-age T2DM patients with right DLPFC-posterior parietal lobe and parahippocampal gyrus default network causes impairment of spatial working memory and mild cognitive dysfunction.
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