期刊
CLINICAL GENITOURINARY CANCER
卷 12, 期 5, 页码 E189-E195出版社
CIG MEDIA GROUP, LP
DOI: 10.1016/j.clgc.2014.04.003
关键词
African-American; Health Policy; Population health; Prostatic Neoplasms; SEER
资金
- David and Cynthia Chapin
- Prostate Cancer Foundation
- Fitz's Cancer Warriors
- Hugh Simons in Honor of Frank
- Anne Simons
- anonymous family foundation
This study examined the association of race and prostate cancere-specific mortality (PCSM) in 51,315 men with low-risk prostate cancer, using the Surveillance, Epidemiology, and End Results (SEER) database. African American men were found to have a higher risk of PCSM compared with white men, suggesting that further studies are needed to determine whether guidelines for active surveillance should take race into account. Background: Men with low-risk prostate cancer (CaP) are considered unlikely to die of CaP and have the option of active surveillance. This study evaluated whether African American (AA) men who present with low-risk disease are at higher risk for death from CaP than white men. Patients and Methods: The authors identified 56,045 men with low-risk CaP (T1-T2a, Gleason score <= 6, prostate-specific antigen <= 10 ng/mL) diagnosed between 2004 and 2009 using the Surveillance, Epidemiology, and End Results (SEER) database. Fine-Gray competing-risks regression analyses were used to analyze the effect of race on prostate cancere-specific mortality (PCSM) after adjusting for known prognostic and sociodemographic factors in 51,315 men (43,792 white; 7523 AA) with clinical follow-up information available. Results: After a median follow-up of 46 months, 258 patients (209 [0.48%] white and 49 [0.65%] AA men) died from CaP. Both AA race (adjusted hazard ratio [AHR], 1.45; 95% CI, 1.03-2.05; P = .032) and noncurative management (AHR, 1.49; 95% CI, 1.15-1.95; P = .003) were significantly associated with an increased risk of PCSM. When analyzing only patients who underwent curative treatment, AA race (AHR, 1.62; 95% CI, 1.04-2.53; P = .034) remained significantly associated with increased PCSM. Conclusion: Among men with low-risk prostate cancer, AA race compared with white race was associated with a higher risk of PCSM, raising the possibility that clinicians may need to exercise caution when recommending active surveillance for AA men with low-risk disease. Further studies are needed to ultimately determine whether guidelines for active surveillance should take race into account. (C) 2014 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据