期刊
JOURNAL OF MAGNETIC RESONANCE
卷 260, 期 -, 页码 1-9出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2015.09.001
关键词
MRI; Solid state NMR; Lee-Goldburg decoupling; Constant-time imaging; Microcoil
资金
- Intramural Research Program of the National Institute of Diabetes and Digestive and Kidney Diseases, a component of the National Institutes of Health
We describe and demonstrate a novel apparatus for magnetic resonance imaging (MRI), suitable for imaging of both liquid and solid samples with micron-scale isotropic resolution. The apparatus includes a solenoidal radio-frequency microcoil with 170 mu m inner diameter and a set of planar gradient coils, all wound by hand and supported on a series of stacked sapphire plates. The design ensures efficient heat dissipation during gradient pulses and also facilitates disassembly, sample changes, and reassembly. To demonstrate liquid state H-1 MRI, we present an image of polystyrene beads within CuSO4-doped water, contained within a capillary tube with 100 mu m inner diameter, with 5.0 mu m isotropic resolution. To demonstrate solid state H-1 MRI, we present an image of NH4Cl particles within the capillary tube, with 8.0 mu m isotropic resolution. High-resolution solid state MRI is enabled by frequency-switched Lee-Goldburg decoupling, with an effective rotating frame field amplitude of 289 kHz. At room temperature, pulsed gradients of 4 T/m (i.e., 170 Hz/mu m for H-1 MRI) are achievable in all three directions with currents of 10 A or less. The apparatus is contained within a variable-temperature liquid helium cryostat, which will allow future efforts to obtain MRI images at low temperatures with signal enhancement by dynamic nuclear polarization. Published by Elsevier Inc.
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