期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 37, 页码 10971-10974出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201503652
关键词
aptamers; GFP; molecular evolution; nucleic acids; SELEX
资金
- German Research Council (Deutsche Forschungsgemeinschaft) [Ma 3442/4-1]
A novel and versatile method has been developed for modular expansion of the chemical space of nucleic acid libraries, thus enabling the generation of nucleobase-modified aptamers with unprecedented recognition properties. Reintroduction of the modification after enzymatic replication gives broad access to many chemical modifications. This wide applicability, which is not limited to a single modification, will rapidly advance the application of invitro selection approaches beyond what is currently feasible and enable the generation of aptamers to many targets that have so far not been addressable.
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