期刊
CLINICAL GENETICS
卷 75, 期 2, 页码 101-106出版社
WILEY
DOI: 10.1111/j.1399-0004.2008.01083.x
关键词
complex traits; familial aggregation; genetic epidemiology; gene mapping; statistical genetic modeling; trends in genomics
资金
- US Public Health Service
- National Center for Research Resources [RR03655]
- Multidisciplinary Clinical Research Career Development [KL2RR024990]
- National Institute of General Medical Sciences Research [GM-28356]
- National Cancer Institute Cancer Center [P30CAD43703]
Stein CM, Elston RC. Finding genes underlying human disease.Clin Genet 2009: 75: 101-106. (C) Blackwell Munksgaard, 2008 With the surge in genome-wide association studies (GWAS), many have asked the question 'Are linkage studies dead?' In this article, we survey the approaches used in mapping human disease genes, reviewing the analysis strategies that preceded and laid the groundwork for GWAS. We note that earlier approaches are still useful and the development of new methodology is warranted.
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