期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 10, 页码 3323-3327出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201508288
关键词
encapsulation; hybrid materials; nanostructures; organosilica; protein delivery
资金
- European Research Council for the ERC Advanced Grant [2009-247365]
- Fondation ARC [IHU201301187]
- French Embassy in Italy
- French government [778588G]
The direct delivery of specific proteins to live cells promises a tremendous impact for biological and medical applications, from therapeutics to genetic engineering. However, the process mostly involves tedious techniques and often requires extensive alteration of the protein itself. Herein we report a straightforward approach to encapsulate native proteins by using breakable organosilica matrices that disintegrate upon exposure to a chemical stimulus. The biomolecule-containing capsules were tested for the intracellular delivery of highly cytotoxic proteins into C6 glioma cells. We demonstrate that the shell is broken, the release of the active proteins occurs, and therefore our hybrid architecture is a promising strategy to deliver fragile biomacromolecules into living organisms.
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