Suppression of radiation damping for high precision quantitative NMR

True quantitative analysis of concentrated samples by H-1 NMR is made very difficult by Radiation Damping. A novel NMR sequence (inspired by the WET NMR sequence and by Outer Volume Saturation methods) is therefore proposed to suppress this phenomenon by reducing the spatial area and consequently the number of spins contributing to the signal detected. The size of the detected volume can be easily chosen in a large range and line shape distortions are avoided thanks to a uniform signal suppression of the outer volume. Composition of a mixture can as a result be determined with very high accuracy (precision and trueness) at the per mule level whatever the concentrations and without hardware modification. (C) 2015 Elsevier Inc. All rights reserved.