期刊
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
卷 12, 期 5, 页码 749-755出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cgh.2014.03.007
关键词
Innate Immunity; Gastroenterology; Mucosa; Colitis
资金
- National Institutes of Health [DK058755, DK091987]
- Schneider Family
- Gilman Family
- VAMC
Cells can innately recognize generic products of viruses, bacteria, fungi, or injured tissue by engagement of pattern recognition receptors. Innate immune cells rapidly respond to this engagement to control commensals, thwart pathogens, and/or prompt repair. Insufficient or excessive activation of the innate immune response results in disease. This review focuses on pattern recognition receptors and cells of the innate immune system that are important for intestinal function. Our improving knowledge pertaining to this important aspect of our immune response is opening potential important new therapeutic opportunities for the treatment of disease.
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