期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 17, 页码 5122-5126出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201411059
关键词
deoxygenation; heterogeneous catalysis; ketones; palladium; silanes
Herein, a practical and mild method for the deoxygenation of a wide range of benzylic aldehydes and ketones is described, which utilizes heterogeneous Pd/C as the catalyst together with the green hydride source, polymethylhydrosiloxane. The developed catalytic protocol is scalable and robust, as exemplified by the deoxygenation of ethyl vanillin, which was performed on a 30 mmol scale in an open-to-air setup using only 0.085 mol% Pd/C catalyst to furnish the corresponding deoxygenated product in 93% yield within 3 hours at room temperature. Furthermore, the Pd/C catalyst was shown to be recyclable up to 6 times without any observable decrease in efficiency and it exhibited low metal leaching under the reaction conditions.
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