期刊
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
卷 7, 期 2, 页码 183-191出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cgh.2008.10.008
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Background & Aims: Several bowel-sparing techniques have been proposed for treating patients with CD, but there have been no prospective studies analyzing risk factors and long-term outcome. We prospectively evaluated safety and long-term efficacy of conservative surgery for patients with complicated CD. Methods: From 19932007, 393 of 502 consecutive patients, underwent surgery for complicated CD of the small bowel. Those with colonic involvement were excluded. The Student t test, chi(2) test, Kaplan-Meier estimates, and Cox proportional hazard model were used to analyze postoperative complications and long-term outcome, Results: A total of 865 jejunoileal segments underwent 318 small bowel resections and 367 strictureplasties (either classic or non conventional). There were no deaths; the complication rate was 5.6%, and the cumulative 10-year recurrence rate was 35%. None of the prognostic factors were correlated with postoperative complications. Younger age, an upper jejunoileal location, stricturing behavior, and small-bowel wall thickening 12 months after surgery showed hazard ratios of 2.4 (95% confidence interval [CI], 1-5.4; P = .03), 2.5 (95% CI, 1.3-4.7; P = .004), 2.2 (95% CI, 1.1-4.1; P = .01), and 4.5 (95% CI, 2.3-8.6, P = .000), respectively. Immunomodulator therapy failed to reduce long-term surgical recurrence. Conclusions: Young patients with extended and stricturing disease are at high risk for disease recurrence after surgery. Bowel. wall thickening was a reliable prognostic factor for these patients. Conservative surgery is safe and effective in treating patients with jejunoileal CD and should be considered as the first-line surgical treatment, preventing the risk of short bowel syndrome caused by repeated resections.
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