期刊
CLINICAL ENDOCRINOLOGY
卷 81, 期 6, 页码 921-928出版社
WILEY-BLACKWELL
DOI: 10.1111/cen.12556
关键词
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资金
- University of Pisa [Fondi d'Ateneo]
ObjectiveThe syndrome of resistance to thyroid hormone (RTH) is caused by a mutation of TH receptor (TR) in 80% of cases. Patients without mutation (non-TR-RTH) may have a biochemical pattern that is difficult to differentiate from that of pituitary TSH-secreting adenoma (TSHoma). Herein, we report a large monocentric series of RTH focusing on patients with non-TR-RTH, to evaluate possible clinical or biochemical parameters able to distinguish them from TSHoma. Design and patientsWe retrospectively reviewed the data of 99 consecutive patients with inappropriate TSH secretion (IST) syndrome referred to our Department between 1983 and 2011, identifying 68 patients with RTH and 31 patients with TSHomas. MeasurementsPatient records were reviewed for the main clinical, biochemical and imaging characteristics. ResultsOf our 68 patients with RTH, 16 (235%) did not show a TR mutation and did not have affected family members. Of these 16 patients, three developed a TSHoma, during follow-up. To distinguish non-TR-RTH from TSHoma, we identified appropriate cut-off values for the main biochemical parameters that demonstrated the greatest sensitivity and specificity (T3 suppression test, -subunit/TSH molar ratio, -subunit assay and TRH test) and we calculated the probability for each patient to develop a TSHoma. ConclusionsThe application of the identified cut-offs could become a very useful tool in the challenging differential diagnosis between sporadic non-TR-RTH and TSHoma. It would then be possible to select the patients at higher risk of developing a TSHoma and therefore needing a closer follow-up.
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