期刊
CLINICAL ENDOCRINOLOGY
卷 81, 期 6, 页码 862-870出版社
WILEY
DOI: 10.1111/cen.12496
关键词
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资金
- Center for Translational Molecular Medicine
- project PREDICCt [01C-104]
- Dutch Obesity Clinic
ObjectiveTo study the effect of different weight loss strategies on levels of the metabolic regulator FGF21 in morbidly obese females with normal glucose tolerance (NGT) or type 2 diabetes mellitus (T2DM). DesignObservational intervention trial. Patients and measurementsWeight reduction was achieved by Gastric Banding (GB, n=11) or Roux-en-Y Gastric Bypass (RYGB, n=16) in subjects with NGT, and by RYGB (n=15) or a very-low-calorie diet (VLCD, n=12) in type 2 diabetics. Fasted and/or postprandial levels of FGF21, FGF19 (an FGF21-related postprandial hormone) and bile salts (implicated in regulation of FGF21 and FGF19 expression) were measured before, and 3 and 12weeks after intervention. ResultsFasted FGF21 levels were elevated in T2DM subjects. Calorie restriction by either GB or VLCD lowered bile salt and FGF21 levels. In contrast, RYGB surgery was associated with elevated bile salt and FGF21 levels. ConclusionsCalorie restriction and RYGB have opposite effects on serum bile salt and FGF21 levels. Calorie restriction results in FGF21 approaching nonobese control levels, suggesting that this intervention is effective in reducing the nutritional crisis that appears to underly FGF21 elevation in obesity. FGF21 elevation after RYGB may contribute to the beneficial effect of this procedure.
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