期刊
CLINICAL EEG AND NEUROSCIENCE
卷 40, 期 1, 页码 31-38出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/155005940904000110
关键词
Adolescence; Alcohol; Alcoholism; Diffusion Tensor Imaging; Functional Magnetic Resonance Imaging; Hangover; Magnetic Resonance Imaging; Withdrawal
资金
- NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM [R01AA013419, F31AA018940] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [R01DA021182] Funding Source: NIH RePORTER
- NIAAA NIH HHS [R01 AA13419, F31 AA018940-01, R01 AA013419-07, F31 AA018940-02, R01 AA013419, F31 AA018940] Funding Source: Medline
- NIDA NIH HHS [R01 DA021182-03, R01 DA02118, R01 DA021182] Funding Source: Medline
Adolescence is a unique period in neurodevelopment. Alcohol and marijuana use are common. Recent research has indicated that adolescent substance users show abnormalities on measures of brain functioning, which is linked to changes in neurocognition over time, Abnormalities have been seen in brain structure volume, white matter quality, and activation to cognitive tasks, even in youth with as little as 1-2 years of heavy drinking and consumption levels of 20 drinks per month, especially if >4-5 drinks are consumed on a single occasion. Heavy manjuana users show some subtle anomalies too, but generally not the same degree of divergence from demographically similar non-using adolescents. This article reviews the extant literature on neurocognition, brain structure, and brain function in adolescent substance users with an emphasis on the most commonly used substances, and in the context of ongoing neuromaturational processes. Methodological and treatment implications are provided.
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