期刊
CLINICAL COLORECTAL CANCER
卷 10, 期 2, 页码 142-145出版社
CIG MEDIA GROUP, LP
DOI: 10.1016/j.clcc.2011.03.012
关键词
Anal squamous cell carcinoma; Anemia; Drug toxicity; Prednisone; Thrombocytopenia
类别
Mitomycin-C (MMC) is a first-line therapy for anal squamous cell carcinoma (ASCC), and it continues to be used for several other indications. Thrombotic thrombocytopenic purpura (TIP) and hemolytic uremic syndrome (HUS) are serious complications of MMC therapy. Herein, we describe a 73-year-old woman with recurrent ASCC treated with MMC who developed chronic microangiopathic hemolytic anemia (MAHA) and thrombocytopenia after receiving a cumulative dose of 50 mg/m(2). These hematologic adverse events persisted for 9 months and resolved after discontinuation of chemotherapy followed by multiple courses of oral corticosteroids. This report describes an atypically chronic and mild form of secondary TTP/HUS and discusses the possible role of corticosteroids in its management.
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