期刊
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
卷 51, 期 3, 页码 623-632出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/cclm-2012-0551
关键词
carotid body; cysteine; hypoxia; thiosulfate; vascular smooth muscle
资金
- National Science Foundation [IBN 0235223, IOS 0641436, IOS 1051627]
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [1051627] Funding Source: National Science Foundation
The ability to monitor oxygen (O-2) availability and delivery is crucial to an animal's survival. Vertebrates have a number of O-2 'sensing' cells that monitor environmental oxygen and ensure adequate delivery to the tissues. While there is little doubt that these cells perform important homeostatic functions, there is little consensus on how a change in O-2 concentration, or partial pressure (pO(2)), is transduced into a physiological response. We recently proposed that the metabolism of hydrogen sulfide (H2S) functions as the O-2 sensor in a variety of tissues. In this mechanism, the concentration of biologically active H2S is regulated by the simple balance between constitutive H2S production and its oxidation by mitochondria. This hypothesis is supported by a number of experimental observations in a wide range of O-2 sensing tissues: 1) exogenous H2S produces the same physiological response as hypoxia; 2) cellular H2S production is inversely related to pO(2) at physiologically relevant pO(2)s; 3) agonists and antagonists of H2S biosynthesis augment and inhibit hypoxic responses, respectively; and 4) H2S and hypoxia appear to act via common effector pathways. The reciprocal relationship between H2S and O-2 also has a long evolutionary history suggesting these gases have been inexorably intertwined throughout evolution. The intent of this review is to elaborate on the mechanism of H2S-mediated O-2 sensing.
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