期刊
CLINICAL CHEMISTRY
卷 59, 期 4, 页码 617-628出版社
OXFORD UNIV PRESS INC
DOI: 10.1373/clinchem.2012.187617
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资金
- NIH [P30 DK56338-06A2, UH3 DK083990, R01 AT004326-01A1, R01 DK065075-01]
BACKGROUND: Obesity, metabolic syndrome, and type 2 diabetes are major public health challenges. Recently, interest has surged regarding the possible role of the intestinal microbiota as potential novel contributors to the increased prevalence of these 3 disorders. CONTENT: Recent advances in microbial DNA sequencing technologies have resulted in the widespread application of whole-genome sequencing technologies for metagenomic DNA analysis of complex ecosystems such as the human gut. Current evidence suggests that the gut microbiota affect nutrient acquisition, energy harvest, and a myriad of host metabolic pathways. CONCLUSION: Advances in the Human Microbiome Project and human metagenomics research will lead the way toward a greater understanding of the importance and role of the gut microbiome in metabolic disorders such as obesity, metabolic syndrome, and diabetes. (C) 2013 American Association for Clinical Chemistry
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