期刊
CLINICAL CANCER RESEARCH
卷 20, 期 18, 页码 4737-4739出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-14-0821
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- NCI NIH HHS [R01 CA052814, CA 52814] Funding Source: Medline
Anthracyclines are active clinical agents that have multiple mechanisms of cytotoxicity. Cardiotoxicity by anthracyclines limits the therapeutic potential of these agents, but mechanisms leading to cardiotoxicity remain controversial. Transgenic mice that lack mitochondrial topoisomerase I are hypersensitive to doxorubicin cardiotoxicity, providing support for cardiotoxicity arising from damage of mitochondrial DNA. (C)2014 AACR.
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