4.7 Editorial Material

Are Short Telomeres Hallmarks of Cancer Recurrence?

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CLINICAL CANCER RESEARCH
卷 20, 期 4, 页码 779-781

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AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-13-3198

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  1. NASA [NNX11AC15G, NNJ05HD36G, NNX09AU95G]
  2. Simmons Cancer Center [5P30CA 142543]
  3. Southland Financial Corporation Distinguished Chair in Geriatric Research
  4. NIH [C06 RR30414]
  5. NASA [148861, NNX11AC15G] Funding Source: Federal RePORTER

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Exposure to radiation and some chemotherapeutic agents is associated with an increased risk of developing second cancers. Short telomeres are almost universally associated with malignant cancer progression. An unanswered question is whether inherited short telomeres or therapy-related telomere shortening is a biomarker of the development of second malignant neoplasms. (C)2013 AACR.

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