期刊
CLINICAL CANCER RESEARCH
卷 18, 期 16, 页码 4257-4265出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-12-0315
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资金
- National Institutes of Health [CA-62924, NCI R01CA-97075]
Pancreatic cancer is caused by inherited and acquired mutations in specific cancer-associated genes. The discovery of the most common genetic alterations in pancreatic cancer has provided insight into the fundamental pathways that drive the progression from a normal cell to noninvasive precursor lesions and finally to widely metastatic disease. In addition, recent genetic discoveries have created new opportunities to develop gene-based approaches for early detection, personalized treatment, and molecular classification of pancreatic neoplasms. Clin Cancer Res; 18(16); 4257-65. (C) 2012 AACR.
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