期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 30, 页码 8791-8794出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201502860
关键词
asymmetric catalysis; hydrogenation; iridium; ketoesters; spiro ligands
资金
- National Natural Science Foundation of China
- National Basic Research Program of China [2012CB821600]
- Ministry of Education of China [B06005]
The chiral tridentate spiro P-N-S ligands (SpiroSAP) were developed, and their iridium complexes were prepared. Introduction of a 1,3-dithiane moiety into the ligand resulted in a highly efficient chiral iridium catalyst for asymmetric hydrogenation of -alkyl--ketoesters, producing chiral -alkyl--hydroxyesters with excellent enantioselectivities (95-99.9% ee) and turnover numbers of up to 355000.
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