期刊
CLINICAL CANCER RESEARCH
卷 16, 期 21, 页码 5303-5311出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-10-0382
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资金
- NIH [PO1 CA33049, RO1 55349]
- Leroy Foundation
- Experimental Therapeutics Center
- Lauri Stauss Leukemia Foundation
- Lymphoma Foundation
- Actinium Pharmaceuticals, Inc. (Florham Park, NJ)
Purpose: Lintuzumab (HuM195), a humanized anti-CD33 antibody, targets myeloid leukemia cells and has modest single-agent activity against acute myeloid leukemia (AML). To increase the potency of the antibody without the nonspecific cytotoxicity associated with alpha-emitters, the a-particle-emitting radionuclide bismuth-213 (Bi-213) was conjugated to lintuzumab. This phase I/II trial was conducted to determine the maximum tolerated dose (MTD) and antileukemic effects of Bi-213-lintuzumab, the first targeted alpha-emitter, after partially cytoreductive chemotherapy. Experimental Design: Thirty-one patients with newly diagnosed (n = 13) or relapsed/refractory (n = 18) AML (median age, 67 years; range, 37-80) were treated with cytarabine (200 mg/m(2)/d) for 5 days followed by Bi-213-lintuzumab (18.5-46.25 MBq/kg). Results: The MTD of Bi-213-lintuzumab was 37 MB/kg; myelosuppression lasting >35 days was dose limiting. Extramedullary toxicities were primarily limited to grade <= 2 events, including infusion-related reactions. Transient grade 3/4 liver function abnormalities were seen in five patients (16%). Treatment-related deaths occurred in 2 of 21 (10%) patients who received the MTD. Significant reductions in marrow blasts were seen at all dose levels. The median response duration was 6 months (range, 2-12). Biodistribution and pharmacokinetic studies suggested that saturation of available CD33 sites by 213Bi-lintuzumab was achieved after partial cytoreduction with cytarabine. Conclusions: Sequential administration of cytarabine and Bi-213-lintuzumab is tolerable and can produce remissions in patients with AML. Clin Cancer Res; 16(21); 5303-11. (C)2010 AACR.
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