期刊
CLINICAL CANCER RESEARCH
卷 16, 期 15, 页码 3822-3824出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-10-1333
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资金
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0846429] Funding Source: National Science Foundation
- NCI NIH HHS [R21 CA139272-02S1, R21 CA139272-01, R21 CA139272-02, R21 CA139272] Funding Source: Medline
- NHLBI NIH HHS [R01 HL098472-01, R01 HL098472-02, R01 HL098472] Funding Source: Medline
- NINDS NIH HHS [R01 NS063405-02, R01 NS063405-03, R01 NS063405-01] Funding Source: Medline
A sensitive and specific fluorescence resonance energy transfer (FRET) biosensor was developed by Mizutani and colleagues and applied to detect the activity of BCR-ABL kinase in live cells. This biosensor allowed the detection of cancerous and drug-resistant cells, and the evaluation of kinase inhibitor efficacy. Future biosensor development and imaging can increasingly contribute to cancer diagnosis and therapeutics. Clin Cancer Res; 16(15); 3822-4. (C) 2010 AACR.
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