期刊
CLINICAL CANCER RESEARCH
卷 14, 期 14, 页码 4372-4377出版社
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-08-0145
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- NCI NIH HHS [CA77495, R01 CA077495, CA104661, R01 CA104661] Funding Source: Medline
- NIEHS NIH HHS [R01 ES012171, R01 ES012171-05, ES012171] Funding Source: Medline
RLIP76 is a multifunctional membrane protein that transports glutathione conjugates of electrophilic compounds and other xenobiotics including chemotherapy agents out of cells. The protein is overexpressed in lung carcinomas, ovarian carcinomas, and melanomas. The protein also binds Ral and participates in mitotic spindle function, clathrin-dependent endocytosis, and triggers GTPase-activating protein activity. It is found throughout the cell, in membrane, cytosol, and the nucleus, and is known to shift between these compartments in response to stress. Loss of RLIP76 by antibody or antisense therapy is associated with increased sensitivity to radiation and chemotherapy. Conversely, liposomally delivered R LIP may treat poisoning and wounds.
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