期刊
CLINICAL BIOMECHANICS
卷 28, 期 9-10, 页码 1055-1060出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.clinbiomech.2013.10.006
关键词
Intermuscular adipose tissue; Muscle; Foot deformity
资金
- National Center for Medical Rehabilitation Research of the National Institute of Child Health and Human Development of the National Institutes of Health [T32 HD007434, K12 HD055931, R24 HD050837]
- National Center for Advancing Translational Sciences of the National Institutes of Health [UL1 RR024992]
Background: Metatarsophalangeal joint deformity is associated with skin breakdown and amputation. The aims of this study were to compare intrinsic foot muscle deterioration ratios (ratio of adipose to muscle volume), and physical performance in subjects with diabetic neuropathy to controls, and determine their associations with 1) metatarsophalangeal joint angle and 2) history of foot ulcer. Methods: 23 diabetic, neuropathic subjects [59 (SD 10) years] and 12 age-matched controls 157 (SD 14) years] were studied. Radiographs and MRI were used to measure metatarsophalangeal joint angle and intrinsic foot muscle deterioration through tissue segmentation by image signal intensity. The Foot and Ankle Ability Measure evaluated physical performance. Findings: The diabetic, neuropathic group had a higher muscle deterioration ratio [1.6 (SD 1.2) vs. 03 (SD 02), P < 0.001], and lower Foot and Ankle Ability Measure scores [65.1 (SD 24.4) vs. 98.3 (SD 33) %, P < 0.01]. The correlation between muscle deterioration ratio and metatarsophalangeal joint angle was r = -0.51 (P = 0.01) for all diabetic, neuropathic subjects, but increased to r = -0.81 (P < 0.01) when only subjects with muscle deterioration ratios >1.0 were included. Muscle deterioration ratios in individuals with diabetic neuropathy were higher for those with a history of ulcers. Interpretation: Individuals with diabetic neuropathy had increased intrinsic foot muscle deterioration, which was associated with second metatarsophalangeal joint angle and history of ulceration. Additional research is required to understand how foot muscle deterioration interacts with other impairments leading to forefoot deformity and skin breakdown. (C) 2013 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据