期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 55, 期 5, 页码 1797-1800出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201510602
关键词
asymmetric synthesis; Conia-ene reaction; organocatalysis; pyrazolones; silver catalysis
资金
- European Research Council (ERC) [320493]
A stereoselective one-pot synthesis of spiropyrazolones through an organocatalytic asymmetric Michael addition and a formal Conia-ene reaction has been developed. Depending on the nitroalkene, the 5-exo-dig-cyclization could be achieved by silver-catalyzed alkyne activation or by oxidation of the intermediate enolate. The mechanistic pathways have been investigated using computational chemistry and mechanistic experiments.
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