期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 98, 期 6, 页码 945-952出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1189/jlb.5MR0315-127R
关键词
translation; immunity
资金
- Inflammation and the Host Response to Injury Large Scale Collaborative Research Program [GG U54 GM062119]
- U.S. National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS)
- NIH - NIGMS [R01 GM40586-24, R01 GM-081923-06]
- NIH NIGMS [R01 GM105893-01A1]
- NIH National Institute on Aging [P30 AG028740]
- NIGMS [R01 GM113945-01, P50 GM111152-01]
Recent comparisons of the murine and human transcriptome in health and disease have called into question the appropriateness of the use of murine models for human sepsis and trauma research. More specifically, researchers have debated the suitability of mouse models of severe inflammation that is intended for eventual translation to human patients. This mini-review outlines this recent research, as well as specifically defines the arguments for and against murine models of sepsis and trauma research based on these transcriptional studies. In addition, we review newer advancements in murine models of infection and injury and define what we envision as an evolving but viable future for murine studies of sepsis and trauma.
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