期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 99, 期 2, 页码 279-287出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1189/jlb.4RU0615-254RR
关键词
immune cells; immune molecules; physiopathology
资金
- National Natural Science Foundation of China [81173075, 31100640, 81473223, 81330081]
- China Postdoctoral Science Foundation [2013M540509]
Graft-versus-host disease is a complication in patients undergoing hematopoietic stem cell transplantation. Graft-versus-host disease includes acute graft-versus-host disease and chronic graft-versus-host disease. Host APCs (e.g., dendritic cells and macrophages), effector T cells (e.g., Th1, Th17, and abnormal Th17: regulatory T cell ratio), B cells, and NK cells are implicated in graft-versus-host disease physiopathology. Proinflammation cytokines (e.g., IL-17, IL-1 beta, and TNF-alpha) are increased in graft-versus-host disease. Costimulatory molecules play an important role in inducing graft-versus-host disease. Pattern-recognition receptors, such as TLRs and nucleotide-binding oligomerization domain-like receptors, are critically involved in the pathogenesis of graft-versus-host disease. Complement system C3 mediates Th1/Th17 polarization in human T cell activation and skin graft-versus-host disease. Accumulation of CD26 T cells in graft-versus-host disease target organs was found. As a therapeutic target, soluble CD83 molecules or antibodies have been demonstrated to have therapeutic effects against graft-versus-host disease, and signaling molecules promote the inflammatory and immune process of graft-versus-host disease. These immune cells and molecules could be the predictors of graft-versus-host disease development and the drug targets of the treatments for graft-versus-host disease. This article focuses on major advances on cellular and molecular mechanisms in graft-versus-host disease.
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