期刊
CLINICAL BIOCHEMISTRY
卷 46, 期 15, 页码 1469-1473出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.clinbiochem.2013.05.050
关键词
IL1B; Polymorphisms; Esophageal cancer; Molecular epidemiology
资金
- National Natural Science Foundation of China [81101889, 81000028]
- Jiangsu Province Natural Science Foundation [BK2010333, BK2011481]
- Social Development Foundation of Zhenjiang [SH2010017]
- Changzhou Young Talents and Science-Technology Foundation of Health Bureau [QN201102]
Objective: Esophageal cancer is the sixth leading cause of cancer-associated deaths worldwide and represents a particularly aggressive type of cancer. Genetic polymorphisms may partly explain individual differences in esophageal cancer susceptibility. Designs and methods: We conducted a hospital-based case-control study to evaluate the genetic effects of functional single nucleotide polymorphisms (SNPs) in the interleukin 1 (IL1A and IL1B), IL1f7, IL3 and IL7Ra genes on the development of esophageal cancer. A total of 380 esophageal squamous cell carcinoma (ESCC) cases and 380 controls were recruited for this study. The genotypes were determined using a custom-by-design 48-Plex SNPscan (TM) Kit. Results: When the IL1B rs16944 GG homozygote genotype was used as the reference group, the GA genotype was associated with a significantly decreased risk of ESCC (GA vs. GG: adjusted OR = 0.69, 95% CI = 0.49-0.99, p = 0.041). However, there were no significant associations between the other five SNPs and ESCC risk. Stratified analyses indicated no significantly different risks of ESCC associated with the IL1B rs16944 G > A polymorphism according to sex, age, smoking status or alcohol consumption. IL3 rs2073506 G > A polymorphism was associated with an increased risk for ESCC higher tumor, nodal, and metastatic (TNM) stages. Conclusions: These findings indicated that the functional IL1B rs16944 G > A polymorphism might contribute to ESCC susceptibility. IL3 rs2073506 G > A polymorphism was associated with an increased risk for ESCC higher TNM stages. However, the results were based on a limited sample size and larger well-designed studies are warranted to confirm these initial findings. (c) 2013 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
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