期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 98, 期 6, 页码 937-943出版社
WILEY
DOI: 10.1189/jlb.5MR0315-104R
关键词
immunosenescence; Toll-like receptor; polymorphonuclear leukocyte; dendritic cell; systems immunology
资金
- U.S. National Institutes of Health [HHS N272201100019C, U19AI089992, K24 AG042489]
Immunosenescence, describing alterations, including decline of immune responses with age, is comprised of inappropriate elevations, decreases, and dysregulated immune responses, leading to more severe consequences of bacterial and viral infections and reduced responses to vaccination. In adaptive immunity, these changes include increased proportions of antigen-experienced B and T cells at the cost of naive cell populations. Innate immune changes in aging are complex in spanning multiple cell types, activation states, and tissue context. Innate immune responses are dampened in aging, yet there is also a paradoxical increase in certain signaling pathways and cytokine levels. Here, we review recent progress and highlight novel directions for expected advances that can lead the aging field to a new era of discovery that will embrace the complexity of aging in human populations.
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