期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 99, 期 1, 页码 67-78出版社
WILEY
DOI: 10.1189/jlb.3MR0615-272RR
关键词
infection; Toll-like receptors; cytokines; innate immune cells
资金
- Cincinnati Children's Hospital Medical Center (CCHMC) Perinatal Institute Pilot and Feasibility Award
- Burroughs Wellcome Fund Preterm Birth Research Grant [1015032]
Preterm birth is the leading cause of neonatal morbidity and mortality. Although the underlying causes of pregnancy-associated complication are numerous, it is well established that infection and inflammation represent a highly significant risk factor in preterm birth. However, despite the clinical and public health significance, infectious agents, molecular trigger(s), and immune pathways underlying the pathogenesis of preterm birth remain underdefined and represent a major gap in knowledge. Here, we provide an overview of recent clinical and animal model data focused on the interplay between infection-driven inflammation and induction of preterm birth. Furthermore, here, we highlight the critical gaps in knowledge that warrant future investigations into the interplay between immune responses and induction of preterm birth.
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