期刊
JOURNAL OF LEUKOCYTE BIOLOGY
卷 99, 期 1, 页码 45-50出版社
FEDERATION AMER SOC EXP BIOL
DOI: 10.1189/jlb.3MR0315-136R
关键词
hematology; chemokines; immune evasion
资金
- Deutsche Forschungsgemeinschaft [KU1315/7-1, GRK1431]
The cellular microenvironment in HL is dominated by amixed infiltrate of inflammatory cells with typically only 1 or a few percent of HRS tumor cells. HRS cells orchestrate this infiltrate by the secretion of a multitude of chemokines. T cells are usually the largest population of cells in the HL tissue, encompassing Th cells, T-regs, and CTLs. Th cells and Tregs presumably provide essential survival signals for the HRS cells, and the Tregs also play an important role in rescuing HRS cells from an attack by CTLs and NK cells. The interference with this complex interplay of HRS cells with other immune cells in the microenvironment may provide novel strategies for targeted immunotherapies.
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