Epidemiological association between fasting plasma glucose and shortened APTT

Objectives: To investigate the relationship between fasting plasma glucose (FPG) and shortened activated partial thromboplastin time (APTT), an independent risk factor for thrombosis. Design and methods: We analyzed outpatients' results of coagulation tests and FPG. Results: When compared with euglycemic subjects, those with impaired fasting glucose and diabetes displayed significantly shortened APTTs. Conclusions: This previously unreported association deserves scrutiny, because APTT is relatively inexpensive and it might identify diabetic patients at major risk of thrombosis. (C) 2008 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.