期刊
CLINICAL BIOCHEMISTRY
卷 42, 期 10-11, 页码 1019-1024出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.clinbiochem.2009.03.013
关键词
Albuminuria; Dyslipidemia; Lipoprotein(a); Apolipoprotein B; Triglyceride; Type 2 diabetes
资金
- New Century Health Care Promotion Foundation
- Department of Health [DOH89-TD-1035, DOH97-TD-D-113-97009]
- National Taiwan University Hospital Yun-Lin Branch [NTUHYL96.G001]
- National Science Council, Taiwan [NSC-86-2314-B-002326, NSC-87-2314-B-002-245, NSC88-2621-B-002-030, NSC89-2320-B002-125, NSC-90-2320-B-002-197, NSC-922320-B-002-156, NSC-93-2320-B-002-071, NSC-94-2314-B002-142, NSC-95-2314-B-002-311, NSC-96-2314-B-002061-MY2]
Background: This study evaluated the lipid abnormalities associated with different stages of albuminuria in type 2 diabetic patients. Methods and results: A total of 549 patients (245 men and 304 women) with mean age of 63.4 were studied. Normoalbuminuria (n=251), microalbuminuria (n=242) and macroalbuminuria (n=56) were defined as albumin-to-creatinine ratio of < 30, 30-299 and >= 300 mu g/mg, respectively. Lipid parameters included total cholesterol, triglyceride (TG), high- and low-density lipoprotein (LDL) cholesterol, apolipoproteins A1 and B (ApoB), and lipoprotein(a) [Lp(a)]. Results showed that ApoB differed significantly (p < 0.05) between normoalbuminuria and microalbuminuria/macroalbuminuria and Ln[Lp(a)] differed between normoalbuminuria/microalbuminuria and macroalbuminuria. Ln(TG) increased progressively with increasing albuminuria. In multivariate logistic regression analyses, only ApoB showed significant odds ratio (95% confidence interval) for microalbuminuria: 1.013 (1.004-1.022); and both ln(TG) and ln[Lp(a)] were significant for macroalbuminuria [respective odds ratios: 1.995 (1.010-3.938) and 1.708 (1.200-2.430)]. Conclusions: A differential dyslipidemia is observed for microalbuminuria and macroalbuminuria. Apo(B) and Lp(a) increase at the stages of microalbuminuria and macroalbuminuria, respectively. However, TG increases significantly throughout the three stages of albuminuria. (c) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
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