期刊
CLINICAL BIOCHEMISTRY
卷 41, 期 18, 页码 1461-1465出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.clinbiochem.2008.08.088
关键词
Acidosis; Fetal blood sampling; Lactate; Point of care testing
Objective: To validate a point of care lactate device to replace total pH measurement. Study design and methods: Cord blood samples drawn immediately following delivery were tested on the Nova Lactate Plus and ARKRAY Lactate Pro. the Corometrics 220 pH System, and the Vitros chemistry analyzer (used as lactate reference). Results: Nova demonstrated a constant Positive bias relative to the lactate reference method while the Lactate Pro correlated well with the reference method LIP to 6 mmol/L. Receiver operating characteristic (ROC) curve analysis showed optimal sensitivity and specificity for predicting pH < 7.20 at lactate values of 6.8 mmol/L for the Nova and 4.8 mmol/L for the Lactate Pro. Conclusion: Using Lactate Pro the best cut-off for predicting pH <= 7.20 was 4.8 mM which coincides with current clinical cut-offs. Thus any lactate device that correlates well with the laboratory reference method call be used with a clinical cut-off of 4.8 mmol/L. (c) 2008 The Canadian Society of-Clinical Chemists. Published by Elsevier Inc. All rights reserved.
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