期刊
CLINICAL AUTONOMIC RESEARCH
卷 23, 期 1, 页码 9-14出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s10286-012-0169-3
关键词
Sympathetic nerve activity; Human obesity
资金
- ARDIAN Inc. Servier
- Abbot
- Allergan
Excess adiposity is associated with increased incidence of cardiovascular disease (CVD). Importantly, CVD mortality associated with obesity is more prevalent in young individuals. Elevated sympathetic nervous system (SNS) activity is present in obesity, even in individuals who are young and otherwise healthy. Baseline SNS overactivity, as well as blunted sympathetically mediated thermogenic response to a meal may play a critical role in the development and progression of CVD which is likely to develop as a result of multiple factors. Recent data indicate that SNS activity to the skeletal muscle is directly related to the degree of renal, endothelial and cardiac dysfunction in young individuals. Targeting the SNS may be an attractive and important avenue for the pharmacological treatment of obesity-related disturbances.
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