期刊
CLINICAL AND VACCINE IMMUNOLOGY
卷 21, 期 5, 页码 777-782出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00003-14
关键词
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资金
- National Institutes of Health [T32 AI055429]
- NIH [5R43AI91078, AI098774]
- NIH/OD [OD-011104-51]
Recent incidents in the United States and abroad have heightened concerns about the use of ricin toxin as a bioterrorism agent. In this study, we produced, using a robust plant-based platform, four chimeric toxin-neutralizing monoclonal antibodies that were then evaluated for the ability to passively protect mice from a lethal-dose ricin challenge. The most effective antibody, c-PB10, was further evaluated in mice as a therapeutic following ricin exposure by injection and inhalation.
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