期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 49, 页码 14800-14804出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201507020
关键词
enzyme catalysis; polymers; self-assembly; supramolecular chemistry; surface chemistry
资金
- Swiss commission for technology and innovation [12608.2PFEN-NM]
- Swiss State Secretariat for Education, Research and Innovation (EU-H2020 INMARE project)
To be used successfully in continuous reactor systems, enzymes must either be retained using filtration membranes or immobilized on a solid component of the reactor. Whereas the first approach requires large amounts of energy, the second approach is limited by the low temporal stability of enzymes under operational conditions. To circumvent these major stumbling blocks, we have developed a strategy that enables the reversible supramolecular immobilization of bioactive enzyme-polymer conjugates at the surface of filtration membranes. The polymer is produced through a reversible addition-fragmentation transfer method; it contains multiple adamantyl moieties that are used to bind the resulting conjugate at the surface of the membrane which has surface-immobilized cyclodextrin macrocycles. This supramolecular modification is stable under operational conditions and allows for efficient biocatalysis, and can be reversed by competitive host-guest interactions.
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